I would say if you like Live over ESPN then give March Madness a rent first. Both ESPN games do feel similar and like DB said on default the college game is slower, especially with the chugbutts (Centers and Power Forwards) rumbling up and down the court.I am happy and all that people are happy but don't animations like fade away threes and the 2 foot lean back hook shot ruin the game for you?
I'm hesitant to pick it up because I know that will piss me off to no end.
Live's animations are so smooth.
As for my time with ESPN
It is safe to say the fadeaways and leaners have been toned down alot. I am impressed with the number of animations added throughout the game from players being knocked down on picks and screens to defenders spinning around the screens. Like the Pro game you have alot of new animations as you head to the rim. Sure the hook shot from up close is there but not as bad as previous versions. Playing around with pump fakes, how long you hold the shoot button and direction you are going helps cut it to a minimum. As has been mentioned above the CPU will shoot the 3 and they pass the ball around looking for the open shot. You really have to be careful running a zone this year because a 3 point shooting team will kill you if you don't have the pressure bumped up. Fouls are abundant and you will find yourself thinking about each player under your control as you reach in on defense. I have not had many calls on the CPU reaching in but they will foul you in the lane and often. New free throw shooting is exactly what I needed, no more annoying trigger.
On the graphics end it looks as good if not better then ESPN 2K5 but after playing a game at the United Spirit Center (Texas Tech) I have to give the art team a large pat on the back with how they did the crowds. BEST CROWDS EVER! So shoot me I like my atmosphere to go along with gameplay.
Couple of questions regarding controller setup. I went with "C" to match the Pro game. By doing this you do not have access to "lead pass". Am I missing anything with this? On a rebound I have no problem getting fast breaks using the pass icons. One big gripe with this configuation it will not let me choose who I am going to pass to after a made shot by hitting "Y" for pass icon. It bring the icons up but always passes to the PG automatically. Anyone else have this problem? It would be helpful in a full court press. The give and go is pretty effective in the game and might even work to well?
So far so good. Can't wait to unlock the Burger King Stadium, Jersey and Crown.

What difficulty is everyone playing on
Currently on All-Conference (going to bump up to All_American when the rosters are done and begin a dynasty) and 15 minutes getting reasonable scores (on average scoring 60-70 per game). If you play with a higher scoring team I could see playing 18 to 20 full minutes to get in the 90's.